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1.
J Am Anim Hosp Assoc ; 58(3): 156-159, 2022 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-35576399

RESUMO

A 9 yr old castrated male miniature schnauzer was diagnosed histopathologically with a mucosal histiocytic sarcoma of the urinary bladder apex, biopsied at the time of surgical cystotomy. Sequential adjuvant chemotherapy, including both lomustine (discontinued because of adverse effects) and then doxorubicin, were employed. A response to both agents was documented. Ultimately, a complete response was achieved following completion of the doxorubicin protocol. A complete response persisted 768 days following diagnosis at last follow-up. Histiocytic sarcoma of the urinary bladder remains a rare diagnosis in veterinary medicine. Only one previous case report is currently published. This case contrasts with the previous case report, which reported a survival of only 2 mo.


Assuntos
Doenças do Cão , Sarcoma Histiocítico , Animais , Doenças do Cão/patologia , Cães , Doxorrubicina/uso terapêutico , Sarcoma Histiocítico/tratamento farmacológico , Sarcoma Histiocítico/veterinária , Lomustina/uso terapêutico , Masculino , Bexiga Urinária/patologia
2.
Can Vet J ; 57(8): 842-6, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27493283

RESUMO

Canine splenic hematoma can be indistinguishable from hemangiosarcoma on clinical presentation and grossly at the time of surgery. However, hemangiosarcoma represents an aggressive malignancy and a misdiagnosis of hematoma would forgo indications for chemotherapy. This study describes a long-term follow-up of cases with a histologic diagnosis of splenic hematoma following splenectomy to determine if the clinical course of the disease corroborated the diagnosis. Thirty-five dogs were evaluated to determine survival and prognostic associations with signalment and clinical data. Overall median survival time was 647 days (range: 0 to 3287 days). Statistically significant variables included a palpable abdominal mass during physical examination, sub-clinical coagulopathy, and metastasis. Four cases (11%) had reported evidence of metastasis at the time of euthanasia; 1 case was histologically confirmed. Overall prognosis for splenic hematoma appears excellent, as expected, but a small proportion of cases may have an undiagnosed malignant component.


Résultats et facteurs de pronostic pour les chiens ayant un diagnostic histologique d'hématomes spléniques après la splénectomie : 35 cas (2001­2013). L'hématome splénique canin peut être indifférenciable de l'hémangiosarcome à la présentation clinique et macroscopiquement au moment de la chirurgie. Cependant, l'hémangiosarcome représente une malignicité agressive et un mauvais diagnostic de l'hématome se traduirait par l'absence de chimiothérapie. Cette étude décrit un suivi à long terme des cas avec un diagnostic histologique de l'hématome splénique après la splénectomie afin de déterminer si l'évolution clinique de la maladie a corroboré le diagnostic. Trente-cinq chiens ont été évalués afin de déterminer les associations de survie et de pronostic avec le signalement et les données cliniques. La durée de survie médiane globale était de 647 jours (fourchette de 0­3287 jours). Les variables statistiquement significatives incluaient une masse abdominale palpable à l'examen physique, une coagulopathie subclinique et la présence de métastases. Quatre cas (11 %) avaient signalé la présence de métastases au moment de l'euthanasie; 1 cas a été confirmé par histologie. Le pronostic général pour un hématome splénique semble excellent, mais une faible proportion de cas peut présenter un élément de malignicité non diagnostiqué.(Traduit par Isabelle Vallières).


Assuntos
Doenças do Cão/enfermagem , Hematoma/veterinária , Esplenectomia/veterinária , Esplenopatias/veterinária , Animais , Doenças do Cão/patologia , Cães , Feminino , Hematoma/patologia , Hematoma/cirurgia , Masculino , Prognóstico , Estudos Retrospectivos , Esplenopatias/patologia , Esplenopatias/cirurgia , Análise de Sobrevida , Resultado do Tratamento
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